How I met St Peregrine

Peregrine

Use of second generation sequencing (SGS) technologies for transcriptional profiling (RNA-Seq) has revolutionized transcriptomics, enabling measurement of RNA abundances with unprecedented specificity and sensitivity and the discovery of novel RNA species. Preparation of RNA-Seq libraries requires conversion of the RNA starting material into cDNA flanked by platform-specific adaptor sequences. ...

How You Met Me

A popular Facebook meme asks a user’s friends to recall how they met that user and then to paste the same query in their own status. We study the spread of this particular meme, which engaged millions of Facebook users, and the insights into relationship formation that the resulting compilation of answers provides. We describe the locations, relationships, and circumstances that contribute to f...

Peregrine breather revisited

How I treat How I treat myelofibrosis

It is currently assumed that myelofibrosis (MF) originates from acquired mutations that target the hematopoietic stem cell and induce dysregulation of kinase signaling, clonal myeloproliferation, and abnormal cytokine expression. These pathogenetic processes are interdependent and also individually contributory to disease phenotype–bone marrow stromal changes, extramedullary hematopoiesis, inef...

How I treat How I treat amyloidosis

Amyloidosis is an uncommon disorder in which proteins change conformation, aggregate, and form fibrils that infiltrate tissues, leading to organ failure and death. The most frequent types are light-chain (AL) derived from monoclonal B-cell disorders producing amyloidogenic immunoglobulin light chains, and the hereditary and “senile systemic” (ATTR) variants from mutant and wild-type transthyret...